麝香保心丸联合阿托伐他汀治疗急性心肌梗死的疗效观察熊(1)

http://www.100md.com 2018年3月1日 《世界中医药》 20185

     摘要目的：探讨麝香保心丸联合阿托伐他汀治疗急性心肌梗死(AMI)的疗效及对患者血管内皮功能和心功能的影响。方法：选取2013年10月至2016年9月四川省人民医院收治的AMI患者81例纳入研究并随机分组，均行常规治疗，对照组40例联合阿托伐他汀治疗，观察组41例在对照组基础上联合麝香保心丸，14 d为1个疗程。比较治疗前后脑钠肽(BNP)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)等心功能，一氧化氮(NO)、内皮素(ET)等血管内皮功能及超敏C反应蛋白(HsCRP)改善情况；比较临床疗效及并发症情况。结果：治疗后，患者BNP、HsCRP、LVEDD、LVESD、ET均降低，LVEF、NO升高，观察组改善更显著(P<005)；对照组总有效率7000%(28/40)，观察组9024%(37/41)，总有效率更高(P<005)；观察组并发症发生率更低(P<005)。结论：麝香保心丸联合阿托伐他汀治疗AMI疗效显著，可更好地保护心脏功能及内皮功能，值得推广。

    关键词麝香保心丸；阿托伐他汀；急性心肌梗死；血管内皮功能；心功能
, 百拇医药
    Effect of Shexiang Baoxin Pill Combined with Atorvastatin on Acute Myocardial Infarction

    and Its Effect on Vascular Endothelial Function and Cardiac Function

    Xiong Wei， Ye Hua， She Shuya， He Lin

    (Sichuan People ′s Hospital， Chengdu 610031， China)

    AbstractObjective：To investigate the effect of Shexiang Baoxin Pill combined with atorvastatin on acute myocardial infarction (AMI) and its effect on vascular endothelial function and cardiac function. Methods：A total of 81 patients admitted to our hospital from October 2013 to September 2016 were included in the study and randomized to receive routine treatment. Forty patients in the control group were treated with atorvastatin and 41 patients in the control group was given Shexiang Baoxin Pill based on the control group， with 14 days for a course of treatment. Brain natriuretic peptide (BNP)， left ventricular ejection fraction (LVEF)， left ventricular enddiastolic dimension (LVEDD)， left ventricular enddiastolic diameter (LVESD)， nitric oxide (NO)， endothelin (ET)， and other vascular endothelial function and high sensitivity Creactive protein (HsCRP) before and after treatment were compared. The clinical efficacy and complications were compared. Results：After treatment， the levels of BNP， HsCRP， LVEDD， LVESD and ET were decreased， and LVEF and NO were increased. The improvement was significant in the observation group (P<005). The total effective rate of the control group was 7000% (28/40) (P<005). The incidence of complications was lower in the observation group (P<005)， and the total effective rate was higher (P<005). Conclusion：Shexiang Baoxin Pill combined with atorvastatin has a significant effect in the treatment of AMI， which can better protect heart function and endothelial function.

    Key WordsShexiang Baoxin pill； Atorvastatin； Acute myocardial infarction； Vascular endothelial function； Cardiac function

    中圖分类号：R25622文献标识码：Adoi：10.3969/j.issn.1673-7202.2018.05.037, 百拇医药(巍叶华 佘姝娅 何林)

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